Cu-catalyzed asymmetric allylic alkylation of phosphonates and phosphine oxides with Grignard reagents.
نویسندگان
چکیده
An efficient and highly enantioselective copper-catalyzed allylic alkylation of phosphonates and phosphine oxides with Grignard reagents and Taniaphos or phosphoramidites as chiral ligands is reported. Transformation of these products leads to a variety of new phosphorus-containing chiral intermediates.
منابع مشابه
Catalytic asymmetric synthesis of chromenes and tetrahydroquinolines via sequential allylic alkylation and intramolecular Heck coupling.
Highly enantioselective synthesis of chiral chromenes and tetrahydroquinolines is achieved by combining asymmetric copper-catalyzed allylic substitution with Grignard reagents and an efficient intramolecular Heck reaction. Moreover, the exocyclic double bond formed in the cyclisation was subjected to RCM, hydroboration and hydrogenation illuminating the synthetic versatility of these heterocycles.
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A catalyst system able to perform highly enantioselective Cu-catalysed allylic alkylations with Grignard reagents is described.
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ورودعنوان ژورنال:
- Chemistry
دوره 19 17 شماره
صفحات -
تاریخ انتشار 2013